Journal of Pathology and Translational Medicine

Case Studies

Hyalinizing Trabecular Tumor of the Thyroid Gland, a Diagnostic Challenge in Fine-Needle Aspiration Cytology: Case Report: Ye-Young Rhee, Hong Kyu Jung, Se Hoon Kim, Soo Hee Kim; J Pathol Transl Med. 2018;52(4):252-256. Published online June 11, 2018; DOI: https://doi.org/10.4132/jptm.2018.04.28

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Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor with low to minimal malignant potential. HTT is often misinterpreted as other thyroid tumors, including papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC), on fine-needle aspiration (FNA) cytology, because of its overlapping cytologic features, such as nuclear grooves and intranulcear pseudoinclusions. Although cytopathologists cannot definitely conclude HTT by FNA cytology, suspicion of HTT is necessary to avoid misdiagnosing HTT as PTC or MTC and to avoid unnecessary aggressive treatment. Here, we report a case of HTT with novel cytologic features in CellPrep liquid based cytology that was diagnosed as suspicious for papillary carcinoma by FNA and finally diagnosed as HTT in the surgical specimen.

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Cytomorphological traits of fine-needle aspirates of hyalinizing trabecular tumor of the thyroid gland: A brief report
Fei Wang, Yufei Liu
Indian Journal of Pathology and Microbiology.2024; 67(1): 128. CrossRef
Total thyroidectomy can still remain the method of choice in some Bethesda III cases
Jindrich Lukas, Barbora Hintnausova, Vlasta Sykorova, Martin Syrucek, Marek Maly, Jaroslava Duskova
Biomedical Papers.2023; 167(1): 61. CrossRef
Diagnostic clues for hyalinizing trabecular tumor on fine needle aspiration cytology
Lone Nielsen, Ana María Colino Gallardo, Pablo Pérez Alonso, Luis Ortega Medina, Esthefanía Latorre García, Cristina Díaz del Arco, Reyes Bergillos Jiménez, Lorenzo Alarcón García, Marta Cruz Blanco, Jesús Vega González, Montserrat De la Torre Serrano, Ma
Cytojournal.2023; 20: 19. CrossRef
Clinical Characteristics of the Hyalinizing Trabecular Tumor
Byung-Chang Kim, Shin Jeong Pak, Jae Won Cho, Won Woong Kim, Yu-mi Lee, Tae-Yon Sung, Jung Hwan Baek, Ki-Wook Chung
Journal of Endocrine Surgery.2022; 22(4): 116. CrossRef
A Case of Multifocal Hyalinizing Trabecular Tumors of the Thyroid Gland
Suhwan Jeong, Hanaro Park
Journal of Clinical Otolaryngology Head and Neck Surgery.2021; 32(3): 308. CrossRef
The Diagnosis of Hyalinizing Trabecular Tumor: A Difficult and Controversial Thyroid Entity
Esther Diana Rossi, Mauro Papotti, William Faquin, Luigi Maria Larocca, Liron Pantanowitz
Head and Neck Pathology.2020; 14(3): 778. CrossRef
A large series of hyalinizing trabecular tumors: Cytomorphology and ancillary techniques on fine needle aspiration
Marco Dell’Aquila, Carmen Gravina, Alessandra Cocomazzi, Sara Capodimonti, Teresa Musarra, Stefania Sfregola, Vincenzo Fiorentino, Luca Revelli, Maurizio Martini, Guido Fadda, Liron Pantanowitz, Luigi Maria Larocca, Esther Diana Rossi
Cancer Cytopathology.2019; 127(6): 390. CrossRef
GLIS rearrangements in thyroid nodules: A key to preoperative diagnosis of hyalinizing trabecular tumor
Marina N. Nikiforova, Yuri E. Nikiforov, N. Paul Ohori
Cancer Cytopathology.2019; 127(9): 560. CrossRef

Merkel Cell Carcinoma Metastatic to Pleural Fluid: A Case Report: Ye-Young Rhee, Soo Hee Kim, Eun Kyung Kim, Se Hoon Kim; J Pathol Transl Med. 2018;52(3):206-209. Published online November 23, 2017; DOI: https://doi.org/10.4132/jptm.2017.11.10

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Abstract PDF

Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine carcinoma of the skin that shows locoregional or distant metastasis. Metastasis of MCC to body cavity effusion is extremely rare; only three cases have been reported so far. Metastatic MCC in effusion cytology shows small blue round cells with fine stippled chromatin like other small blue round cell tumors such as small cell lung carcinoma or lymphoma. The diagnosis of metastatic MCC can grant patients good chances at recently advanced therapeutic options. Here, we present a case of metastatic MCC to pleural effusion with characteristic single file-like pattern.

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Merkel cell carcinoma presenting as a malignant pleural effusion post‐COVID‐19 hospitalization: A case report and literature review
Joel Lanceta, Mesut Toprak, Oana C. Rosca
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Cytology coupled with immunocytochemistry identifies Merkel cell carcinoma: A rare intruder in the cerebrospinal fluid
Reetu Kundu, Brijdeep Singh, Pranab Dey
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Derrame pleural por carcinoma de células de Merkel
María J. Soler-Sempere, María O. Alvárez-Fernández, Isabel Padilla-Navas, María Cabezas-Macián, Jose F. Sánchez-Hernández, Eduardo García-Pachón
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A rare case of pleural localisation of both metastatic Merkel cell carcinoma and chronic lymphocytic leukaemia
Elise Kaspi, Shirley Fritz, Julien Colle, Florent Amatore, Diane Frankel, Patrice Roll
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Merkel cell carcinoma with pleural effusion
María J. Soler-Sempere, María O. Alvárez-Fernández, Isabel Padilla-Navas, María Cabezas-Macián, Jose F. Sánchez-Hernández, Eduardo García-Pachón
Archivos de Bronconeumología (English Edition).2021; 57(11): 715. CrossRef

Original Articles

Diagnostic Accuracy of Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytology of Pancreatic Lesions: Hae Woon Baek, Min Jee Park, Ye-Young Rhee, Kyoung Bun Lee, Min A Kim, In Ae Park; J Pathol Transl Med. 2015;49(1):52-60. Published online January 15, 2015; DOI: https://doi.org/10.4132/jptm.2014.10.26

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Abstract PDF

Background
Endoscopic ultrasound–guided fine needle aspiration cytology (EUS-FNAC) is currently the most commonly used procedure for obtaining cytologic specimens of the pancreas. It is accurate, minimally invasive, safe and cost-effective. However, there is discrepancy between cytological and surgical diagnoses. This study was aimed at evaluating the diagnostic accuracy of EUS-FNAC of the pancreas. Methods: We performed a retrospective review of 191 cases of pancreatic lesions initially diagnosed by EUS-FNAC with subsequent histological diagnosis between 2010 and 2012 in the Department of Pathology, Seoul National University Hospital. Cytologic and surgical diagnoses were categorized into five groups: negative, benign, atypical, malignant, and insufficient for diagnosis. Subsequently, 167 cases with satisfactory yield in both surgical and cytology specimens were statistically analyzed to determine correlations with diagnosis. Results: In comparison to surgical diagnoses, cytologic diagnoses were true-positive in 103 cases (61.7%), true-negative in 28 cases (16.8%), false-positive in 9 cases (5.4%), and false-negative in 27 cases (16.1%). The diagnostic accuracy was 78.4%, sensitivity was 79.2%, and specificity was 75.7%. The positive predictive value was 92.0%, and negative predictive value was 50.9%. Conclusions: EUS-FNAC has high accuracy, sensitivity, specificity and positive predictive value. Overcoming the limitations of EUS-FNAC will make it a useful and reliable diagnostic tool for accurate evaluation of pancreatic lesions.

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Zhenshan Shi, Chengle Ma, Xinming Huang, Dairong Cao
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Gurudutt Gupta, Anila Sharma, Meenakshi Kamboj, Anurag Sharma, Sunil Pasricha, Garima Durga, Anurag Mehta, Avinash Rao
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Jian-Han Lai, Keng-Han Lee, Chen-Wang Chang, Ming-Jen Chen, Ching-Chung Lin
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Cancer-derived small extracellular vesicles: emerging biomarkers and therapies for pancreatic ductal adenocarcinoma diagnosis/prognosis and treatment
Wei Zhang, Douglas H. Campbell, Bradley J. Walsh, Nicolle H. Packer, Dingbin Liu, Yuling Wang
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Maroun Bou Zerdan, Malek Shatila, Dhruv Sarwal, Youssef Bouferraa, Morgan Bou Zerdan, Sabine Allam, Merima Ramovic, Stephen Graziano
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Fieke Froeling, Raffaella Casolino, Antonio Pea, Andrew Biankin, David Chang
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Diagnostic value of various liquid biopsy methods for pancreatic cancer
Yuzhou Zhu, Hao Zhang, Nan Chen, Jianqi Hao, Hongyu Jin, Xuelei Ma
Medicine.2020; 99(3): e18581. CrossRef
Factors affecting cytological results of endoscopic ultrasound guided-fine needle aspiration during learning
Jian-Han Lai, Hsiang-Hung Lin, Ching-Chung Lin
Diagnostic Pathology.2020;[Epub] CrossRef
Comparison between Conventional Smear and Liquid-Based Preparation in Endoscopic Ultrasonography-Fine Needle Aspiration Cytology of Pancreatic Lesions
Soo Hee Ko, Jung-Soo Pyo, Byoung Kwan Son, Hyo Young Lee, Il Whan Oh, Kwang Hyun Chung
Diagnostics.2020; 10(5): 293. CrossRef
Evaluation of Pancreatic Lesions With Endoscopic Ultrasound and Fine Needle Aspiration
Yan Luk, Wong Hoi She, Felix Che Lok Chow, Ka Wing Ma, Simon Hing Yin Tsang, Wing Chiu Dai, Tan To Cheung, Chung Mau Lo
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The applicability of Papanicolaou Society of Cytopathology system on reporting endoscopic ultrasound‐guided fine needle aspiration cytology specimens of pancreatic lesions in situations with limited availability of ancillary tests. Experience at a single
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Circulating Cell-Free DNA-Based Liquid Biopsy Markers for the Non-Invasive Prognosis and Monitoring of Metastatic Pancreatic Cancer
Marta Toledano-Fonseca, M. Teresa Cano, Elizabeth Inga, Rosa Rodríguez-Alonso, M. Auxiliadora Gómez-España, Silvia Guil-Luna, Rafael Mena-Osuna, Juan R. de la Haba-Rodríguez, Antonio Rodríguez-Ariza, Enrique Aranda
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Journal of the American Society of Cytopathology.2019; 8(3): 120. CrossRef
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Liquid Biopsy as Surrogate for Tissue for Molecular Profiling in Pancreatic Cancer: A Meta-Analysis Towards Precision Medicine
Claudio Luchini, Nicola Veronese, Alessia Nottegar, Vera Cappelletti, Maria G. Daidone, Lee Smith, Christopher Parris, Lodewijk A. A. Brosens, Maria G. Caruso, Liang Cheng, Christopher L. Wolfgang, Laura D. Wood, Michele Milella, Roberto Salvia, Aldo Scar
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It is necessary to exam bottom and top slide smears of EUS-FNA for pancreatic cancer
Jong-chan Lee, Haeryoung Kim, Hyoung Woo Kim, Jongchan Lee, Kyu-hyun Paik, Jingu Kang, Jin-Hyeok Hwang, Jaihwan Kim
Hepatobiliary & Pancreatic Diseases International.2018; 17(6): 553. CrossRef
Preoperative EUS-guided FNA: effects on peritoneal recurrence and survival in patients with pancreatic cancer
Sun Hwa Kim, Young Sik Woo, Kwang Hyuck Lee, Jong Kyun Lee, Kyu Taek Lee, Joo Kyung Park, Soo Hoon Kang, Ji Won Kim, Jae Keun Park, Sung-Wook Park
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Performance measures for endoscopic retrograde cholangiopancreatography and endoscopic ultrasound: A European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative
Dirk Domagk, Kofi W Oppong, Lars Aabakken, Laszlo Czakó, Tibor Gyökeres, Gianpiero Manes, Peter Meier, Jan-Werner Poley, Thierry Ponchon, Andrea Tringali, Cristina Bellisario, Silvia Minozzi, Carlo Senore, Cathy Bennett, Michael Bretthauer, Cesare Hassan,
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Dirk Domagk, Kofi W. Oppong, Lars Aabakken, Laszlo Czakó, Tibor Gyökeres, Gianpiero Manes, Peter Meier, Jan-Werner Poley, Thierry Ponchon, Andrea Tringali, Cristina Bellisario, Silvia Minozzi, Carlo Senore, Cathy Bennett, Michael Bretthauer, Cesare Hassan
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Imaging modalities for characterising focal pancreatic lesions
Lawrence MJ Best, Vishal Rawji, Stephen P Pereira, Brian R Davidson, Kurinchi Selvan Gurusamy
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Transglutaminase 2 Expression and Its Prognostic Significance in Clear Cell Renal Cell Carcinoma: Min Jee Park, Hae Woon Baek, Ye-Young Rhee, Cheol Lee, Jeong Whan Park, Hwal Woong Kim, Kyung Chul Moon; J Pathol Transl Med. 2015;49(1):37-43. Published online January 15, 2015; DOI: https://doi.org/10.4132/jptm.2014.10.25

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Abstract PDF

Background
A few recent studies have demonstrated a possible role of transglutaminase 2 (TG2) in tumorigenesis or progression of renal cell carcinoma (RCC). The aim of this study was to examine TG2 expression and its clinicopathologic significance in a large number of human clear cell RCCs (CCRCCs). Methods: We analyzed 638 CCRCC patients who underwent partial or radical nephrectomy between 1995 and 2005. The expression of TG2 was determined by immunohistochemistry and categorized into four groups, according to staining intensity: negative (0), mild (1+), moderate (2+), and strong (3+). Results: TG2 staining intensity was negative in 8.5% of CCRCC (n=54), 1+ in 32.6% (n=208), 2+ in 50.5% (n=322), and 3+ in 8.5% (n=54). Strong TG2 expression was correlated with high Fuhrman nuclear grade (p=.011), high T category (p=.049), metastasis (p=.043) and male sex (p<.001) but not with N category.The survival analysis showed a significant association between strong TG2 expression and worse overall and cancer-specific survival (p=.027 and p=.010, respectively). On multivariate analysis, strong TG2 expression was a marginally significant prognostic indicator for Fuhrman nuclear grade and TNM staging (p=.054). Conclusions: Our study is the first to demonstrate the clinicopathologic significance of TG2 expression in a large number of human CCRCC samples. Strong TG2 expression was associated with high nuclear grade and poor prognosis.

Citations

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Discovery of novel 1H-benzo[d]imidazole-4,7-dione based transglutaminase 2 inhibitors as p53 stabilizing anticancer agents in renal cell carcinoma
Ga-Ram Kim, Joon Hee Kang, Hyeon Joo Kim, Eunji Im, Jinsu Bae, Woo Sun Kwon, Sun Young Rha, Hyun Cheol Chung, Eun Yi Cho, Soo-Youl Kim, Yong-Chul Kim
Bioorganic Chemistry.2024; 143: 107061. CrossRef
Transglutaminase 2 is associated with adverse colorectal cancer survival and represents a therapeutic target
Patrizia Malkomes, Ilaria Lunger, Elsie Oppermann, Johannes Lorenz, Sara Fatima Faqar-Uz-Zaman, Jiaoyan Han, Sabrina Bothur, Paul Ziegler, Katrin Bankov, Peter Wild, Wolf Otto Bechstein, Michael A. Rieger
Cancer Gene Therapy.2023; 30(10): 1346. CrossRef
Transglutaminase Type 2-MITF axis regulates phenotype switching in skin cutaneous melanoma
Silvia Muccioli, Valentina Brillo, Tatiana Varanita, Federica Rossin, Elisabetta Zaltron, Angelo Velle, Giorgia Alessio, Beatrice Angi, Filippo Severin, Anna Tosi, Manuela D’Eletto, Luca Occhigrossi, Laura Falasca, Vanessa Checchetto, Roberto Ciaccio, Ame
Cell Death & Disease.2023;[Epub] CrossRef
The role of transglutaminase 2 in regulation of the balance between autophagy and apoptosis in tumor cells
Yu. A. Gnennaya, O. M. Semenov, N. A. Barlev
Advances in Molecular Oncology.2023; 10(4): 31. CrossRef
Application of a Fluorescence Anisotropy-Based Assay to Quantify Transglutaminase 2 Activity in Cell Lysates
Sandra Hauser, Paul Sommerfeld, Johanna Wodtke, Christoph Hauser, Paul Schlitterlau, Jens Pietzsch, Reik Löser, Markus Pietsch, Robert Wodtke
International Journal of Molecular Sciences.2022; 23(9): 4475. CrossRef
The Biological and Biomechanical Role of Transglutaminase-2 in the Tumour Microenvironment
Robert Tempest, Sonia Guarnerio, Rawan Maani, Jamie Cooper, Nicholas Peake
Cancers.2021; 13(11): 2788. CrossRef
A Precision Strategy to Cure Renal Cell Carcinoma by Targeting Transglutaminase 2
Soo-Youl Kim, Jeffrey W. Keillor
International Journal of Molecular Sciences.2020; 21(7): 2493. CrossRef
Evaluation of nuclear NF-κB, transglutaminase2, and ERCC1 as predictors of platinum resistance in testicular tumors
Alan A. Azambuja, Paula Engroff, Bruna T. Silva, Roberta C. S. Zorzetti, Fernanda B. Morrone
International braz j urol.2020; 46(3): 353. CrossRef
Transglutaminase 2-Mediated p53 Depletion Promotes Angiogenesis by Increasing HIF-1α-p300 Binding in Renal Cell Carcinoma
Seon-Hyeong Lee, Joon Hee Kang, Ji Sun Ha, Jae-Seon Lee, Su-Jin Oh, Hyun-Jung Choi, Jaewhan Song, Soo-Youl Kim
International Journal of Molecular Sciences.2020; 21(14): 5042. CrossRef
Role of Tissue Transglutaminase Catalytic and Guanosine Triphosphate-Binding Domains in Renal Cell Carcinoma Progression
Burge Ulukan, Ajna Bihorac, Tarik Sipahioglu, Robert Kiraly, Laszlo Fesus, Dilek Telci
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Transglutaminase 2: The Maestro of the Oncogenic Mediators in Renal Cell Carcinoma
Ayca Ece Nezir, Burge Ulukan, Dilek Telci
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Richard L. Eckert
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Allosteric inhibition site of transglutaminase 2 is unveiled in the N terminus
Nayeon Kim, Joon Hee Kang, Won-Kyu Lee, Seul-Gi Kim, Jae-Seon Lee, Seon-Hyeong Lee, Jong Bae Park, Kyung-Hee Kim, Young-Dae Gong, Kwang Yeon Hwang, Soo-Youl Kim
Amino Acids.2018; 50(11): 1583. CrossRef
Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition
Seon-Hyeong Lee, Won-Kyu Lee, Nayeon Kim, Joon Kang, Kyung-Hee Kim, Seul-Gi Kim, Jae-Seon Lee, Soohyun Lee, Jongkook Lee, Jungnam Joo, Woo Kwon, Sun Rha, Soo-Youl Kim
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Tissue transglutaminase expression is necessary for adhesion, metastatic potential and cancer stemness of renal cell carcinoma
Yesim Bagatur, Ayca Zeynep Ilter Akulke, Ajna Bihorac, Merve Erdem, Dilek Telci
Cell Adhesion & Migration.2017; : 1. CrossRef
Characterization of clear cell renal cell carcinoma by gene expression profiling
Bryan J. Thibodeau, Matthew Fulton, Laura E. Fortier, Timothy J. Geddes, Barbara L. Pruetz, Samreen Ahmed, Amy Banes-Berceli, Ping L. Zhang, George D. Wilson, Jason Hafron
Urologic Oncology: Seminars and Original Investigations.2016; 34(4): 168.e1. CrossRef
Prognostic role of tissue transglutaminase 2 in colon carcinoma
María Jesús Fernández-Aceñero, Sofía Torres, Irene Garcia-Palmero, Cristina Díaz del Arco, J. Ignacio Casal
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Differential Features of Microsatellite-Unstable Colorectal Carcinomas Depending on EPCAM Expression Status: Jung Ho Kim, Jeong Mo Bae, Kyung-Ju Kim, Ye-Young Rhee, Younghoon Kim, Nam-Yun Cho, Hye Seung Lee, Mee Soo Chang, Gyeong Hoon Kang; Korean J Pathol. 2014;48(4):276-282. Published online August 26, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.276

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Abstract PDF

Background

Recent studies have revealed that a small subset of Lynch syndrome-associated colorectal carcinomas (CRCs) is caused by a germline EPCAM deletion-induced MSH2 epimutation. Based on the finding of this genetic alteration, we investigated the implications of EPCAM expression changes in microsatellite instability-high (MSI-H) CRCs.

Methods

Expression of EPCAM and DNA mismatch repair proteins was assessed by immunohistochemistry in 168 MSI-H CRCs. Using DNA samples of these tumors, MLH1 promoter methylation status was also determined by methylation-specific real-time polymerase chain reaction method (MethyLight).

Results

Among 168 MSI-H CRCs, complete loss (CL) and focal loss (FL) of EPCAM expression was observed in two (1.2%) and 22 (13.1%) cases, respectively. Both of the EPCAM-CL cases were found in MSH2-negative tumors without MLH1 promoter methylation. However, only nine of the 22 EPCAM-FL tumors had MSH2 deficiency. Of the 22 EPCAM-FL tumors, 13 showed MLH1 loss, and among them, nine cases were determined to have MLH1 methylation. EPCAM-FL was significantly associated with advanced stage (p=.043), distant metastasis (p=.003), poor differentiation (p=.001), and signet ring cell component (p=.004).

Conclusions

Loss of EPCAM expression is differentially associated with clinicopathological and molecular features, depending on the completeness of the loss, in MSI-H CRCs.

Citations

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